Torque Spectroscopy of Sequence-Dependent Structural Transitions in DNA
نویسندگان
چکیده
منابع مشابه
Torque measurements reveal sequence-specific cooperative transitions in supercoiled DNA.
B-DNA becomes unstable under superhelical stress and is able to adopt a wide range of alternative conformations including strand-separated DNA and Z-DNA. Localized sequence-dependent structural transitions are important for the regulation of biological processes such as DNA replication and transcription. To directly probe the effect of sequence on structural transitions driven by torque, we hav...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2012
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2011.11.2299